Bcl-2

Your source for information on Bcl-2 Genes and Proteins, and their role in Apoptosis and the Apoptotic Pathway and Disease.

Bcl-2

Bcl-2 denotes a family of genes and proteins found in mammals which control the outer membrane premeability of mitochondria, and most importantly the fate of the cell through programmed cell death, apoptosis. Initially found through gene translocations in follicular lymphoma, a B-cell lymphoma, many more bcl-2 proteins have been identified since.

Bcl-2 proteins can be of two types, those proteins that favor apoptosis, termed pro-apoptotic such as Bak, Bok, Bax and the well-known BAD, or anti-apoptotic, such as bcl-2, bcl-xL and bcl-w. There are a total of 25 bcl-2 family genes. This website is dedicated to the bcl-2 gene and protein family, and has been established to help provide a one stop area for all bcl-2 information, protocols, articles and updates.

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Bcl-2

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TP53 gene and p53 Protein

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